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Index > Protein center > Enpp2(Gene name) > Mouse
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  • Enpp2 (Gene name),
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Protein name ),  ENPP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Enpp2(Npps2;Pdnp2);
    Protein name:
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 2(E-NPP 2);
    Alternative:
    Extracellular lysophospholipase D(LysoPLD);Autotaxin;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
    Subcellular Location:
    Secreted Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
    Protein Attributes:
    Sequence length:
    862
    Sequence:
    50:
    MARQGCFGSY | QVISLFTFAI | GVNLCLGFTA | SRIKRAEWDE | GPPTVLSDSP | 
    100:
    WTNTSGSCKG | RCFELQEVGP | PDCRCDNLCK | SYSSCCHDFD | ELCLKTARGW | 
    150:
    ECTKDRCGEV | RNEENACHCS | EDCLSRGDCC | TNYQVVCKGE | SHWVDDDCEE | 
    200:
    IRVPECPAGF | VRPPLIIFSV | DGFRASYMKK | GSKVMPNIEK | LRSCGTHAPY | 
    250:
    MRPVYPTKTF | PNLYTLATGL | YPESHGIVGN | SMYDPVFDAT | FHLRGREKFN | 
    300:
    HRWWGGQPLW | ITATKQGVRA | GTFFWSVSIP | HERRILTILQ | WLSLPDNERP | 
    350:
    SVYAFYSEQP | DFSGHKYGPF | GPEMTNPLRE | IDKTVGQLMD | GLKQLKLHRC | 
    400:
    VNVIFVGDHG | MEDVTCDRTE | FLSNYLTNVD | DITLVPGTLG | RIRPKIPNNL | 
    450:
    KYDPKAIIAN | LTCKKPDQHF | KPYMKQHLPK | RLHYANNRRI | EDLHLLVERR | 
    500:
    WHVARKPLDV | YKKPSGKCFF | QGDHGFDNKV | NSMQTVFVGY | GPTFKYRTKV | 
    550:
    PPFENIELYN | VMCDLLGLKP | APNNGTHGSL | NHLLRTNTFR | PTLPEEVSRP | 
    600:
    NYPGIMYLQS | DFDLGCTCDD | KVEPKNKLEE | LNKRLHTKGS | TEERHLLYGR | 
    650:
    PAVLYRTSYD | ILYHTDFESG | YSEIFLMPLW | TSYTISKQAE | VSSIPEHLTN | 
    700:
    CVRPDVRVSP | GFSQNCLAYK | NDKQMSYGFL | FPPYLSSSPE | AKYDAFLVTN | 
    750:
    MVPMYPAFKR | VWTYFQRVLV | KKYASERNGV | NVISGPIFDY | NYNGLRDIED | 
    800:
    EIKQYVEGSS | IPVPTHYYSI | ITSCLDFTQP | ADKCDGPLSV | SSFILPHRPD | 
    850:
    NDESCNSSED | ESKWVEELMK | MHTARVRDIE | HLTGLDFYRK | TSRSYSEILT | 
    862:
    LKTYLHTYES | EI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E-NPP 2
    Cat.:
    E1228m
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    96T
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    ELISA Kit for Mouse E-NPP 2
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    E1228h
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    96T
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    ELISA Kit for Mouse E-NPP 2
    Cat.:
    E1228b
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    Packing:
    96T
    ELISA Kit for Mouse E-NPP 2
    Cat.:
    E1228r
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    Packing:
    96T
    CLIA Kit for Mouse E-NPP 2
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    U1228b
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    Packing:
    96T
    CLIA Kit for Mouse E-NPP 2
    Cat.:
    U1228r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse E-NPP 2
    Cat.:
    U1228h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse E-NPP 2
    Cat.:
    U1228m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Mouse E-NPP 2
    Cat.:
    P1228Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E-NPP 2
    Cat.:
    P1228Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E-NPP 2
    Cat.:
    P1228Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E-NPP 2
    Monoclonal Antibody for Mouse E-NPP 2
    Monoclonal Antibody for Mouse E-NPP 2
    Monoclonal Antibody for Mouse E-NPP 2
    Monoclonal Antibody for Mouse E-NPP 2
    Protein for Mouse E-NPP 2
    Protein for Mouse E-NPP 2
    Protein for Mouse E-NPP 2
    Protein for Mouse E-NPP 2

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    References
    1. 1.
      "Assignment of Pdnp2, the gene encoding phosphodiesterase I/nucleotide pyrophosphatase 2, to mouse chromosome 15D2."
      Piao J.-H. , Matsuda Y. , Nakamura H. , Sano K.
      Cytogenet. Cell Genet.87:172-174(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6.
    2. 2.
      "Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
      Giganti A. , Rodriguez M. , Fould B. , Moulharat N. , Coge F. , Chomarat P. , Galizzi J.-P. , Valet P. , Saulnier-Blache J.-S. , Boutin J.A. , Ferry G.
      J. Biol. Chem.283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
      tissue: Adipocyte.
      tissue: Skeletal muscle.
    3. 3.
      "Comparative genomics, experimental biology, and bioinformatics merge to narrow a QTL for HDL cholesterol on mouse chromosome 15 and human chromosome 8."
      Burgess-Herbert S.L. , Shockley K. , Sheehan S. , Bickerstaff L. , Harwood B.I.V. , Shen Y. , Li R. , Churchill G.A. , Paigen B.
      Submitted (2008-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: MRL/MpJ.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Skin.
    5. 5.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Mammary gland.
      tissue: Retina.
    7. 7.
      "Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."
      Boucher J. , Quilliot D. , Pradere J.P. , Simon M.F. , Gres S. , Guigne C. , Prevot D. , Ferry G. , Boutin J.A. , Carpene C. , Valet P. , Saulnier-Blache J.S.
      Diabetologia48:569-577(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;POSSIBLE FUNCTION IN OBESITY
    8. 8.
      "Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase."
      Pradere J.P. , Tarnus E. , Gres S. , Valet P. , Saulnier-Blache J.S.
      Biochim. Biophys. Acta1771:93-102(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE;SUBCELLULAR LOCATION;FUNCTION;GLYCOSYLATION;MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410
    9. 9.
      "Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin."
      Jansen S. , Andries M. , Derua R. , Waelkens E. , Bollen M.
      J. Biol. Chem.284:14296-14302(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERDOMAIN DISULFIDE BOND;MUTAGENESIS OF 851-LEU--THR-853; LEU-851; LYS-852 AND THR-853
    10. 10.
      "Crystal structure of autotaxin and insight into GPCR activation by lipid mediators."
      Nishimasu H. , Okudaira S. , Hama K. , Mihara E. , Dohmae N. , Inoue A. , Ishitani R. , Takagi J. , Aoki J. , Nureki O.
      Nat. Struct. Mol. Biol.18:205-212(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS;FUNCTION;CATALYTIC ACTIVITY;COFACTOR;DISULFIDE BONDS;GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524;SUBCELLULAR LOCATION;MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249
    11. 11.
      "Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling."
      Kato K. , Nishimasu H. , Okudaira S. , Mihara E. , Ishitani R. , Takagi J. , Aoki J. , Nureki O.
      Proc. Natl. Acad. Sci. U.S.A.109:16876-16881(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 51-58
    12. 12.
      "Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe."
      Kawaguchi M. , Okabe T. , Okudaira S. , Nishimasu H. , Ishitani R. , Kojima H. , Nureki O. , Aoki J. , Nagano T.
      ACS Chem. Biol.8:1713-1721(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS AND ZINC;GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524;CATALYTIC ACTIVITY;COFACTOR;DISULFIDE BOND
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